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Well, it simply means that if the nicotine level is too low, your intake wont help your cravings, but if the nicotine content is too high, you could risk unpleasantly harsh throat hits and some undesirable side effects

For example, people who currently smoke are already facing much more severe respiratory risks from cigarette smoking, and the possible harms of adopting ECs (i.e., dual or even synergistic exposures) may be outweighed by the possible benefits (i.e., discontinuing EC use entirely [7], or substantially reducing cigarette consumption [34])

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More than 150,000 people have used this program

[5] The 2010 FDA regulations caused some inconveniences for local tobacco shops in Cullman, Alabama, US