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NMDA induces long-term synaptic depression and dephosphorylation of the GluR1 subunit of AMPA receptors in hippocampus

Not painful Once the needle is through the skin, there are few nerve sensors, making the injection almost painless

Studies published in prestigious medical journals, including the Annals of Internal Medicine and the Journal of the American Medical Association , have shown that physicians can lag behind the latest research by an average of 17 years

One works at the tissue level

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The second is dose and route translation : even where an effect is real in a mouse, the human-equivalent dose is not a simple body-weight scaling, and as the route section above stressed there is no human bioavailability figure to anchor an oral-versus-injected comparison