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Cigarette smoking is also related to a higher susceptibility to pulmonary bacterial and viral infections, inducing structural changes in the respiratory tract and a decrease in immune response

According to 22nd Century, government-funded research is trying to answer a number of questions about low-nicotine cigarettes, including how different nicotine levels in cigarettes affect smoking behavior, at what level nicotine is no longer addictive and whether a gradual or an immediate reduction in cigarettes' nicotine content to non-addictive levels is more favorable for smokers