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However, other pathophysiological modifications within melanoma cells may contribute to therapy resistance [4, 5], demanding for large-scale computational models to simulate the complex physiology of a tumour in an integrated manner and comprehensively foster the identification of alternative therapeutic vulnerabilities applying high throughput in silico approaches [6, 7]
It is postulated that DM-induced oxidative damage may be more significant in erythrocytes than in other cells, due to their high content of iron and polyunsaturated fatty acids, as well as their role as oxygen transporters, with a high degree of exposure to free radicals [320]
Ovarian RNA sequencing revealed more than 400 DEGs between the M group and the control group at the threshold of |log2(M/CTR)| 1
SERS operates based on two primary mechanisms: electromagnetic enhancement and chemical enhancement
