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NRT: Although co-administration of varenicline (1 mg twice daily) and transdermal nicotine (21 mg/day) for up to 12 days did not affect nicotine pharmacokinetics, the incidence of adverse reactions was greater for the combination than for NRT alone [see Drug Interactions (7.1)]

Journal of the American Heart Association, 9 (9), Article e014570

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Longer NRT treatment duration has been investigated in two randomised trials of longer treatment (up to 52 weeks) in comparison to standard course (8 weeks), but the studies found no convincing benefit

Marijuana: respiratory tract effects

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