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Plant lignans and isoflavonoid phytoestrogens can decrease the conversion of androgens to estrone by inhibiting the cytochrome P450 enzyme aromatase, which can play a protective role in PCa

doi: 10.3389/fped.2018.00412 5 JasonLAKatzBZSunnquistMTorresCCotlerJBhatiaS

However, sex differences were not assessed, and prebiotic efficacy may vary by sex

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When pol + bacteria and high concentrations of dichlorvos (0.2 - 0.4%) were used, an all-or-none breakdown of DNA molecules to fragments of very low relative molecular mass occurred which correlated well with lethality