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For example, C16-carnitine (10 M) may impair mitochondrial function in rat ventricular myocytes by accelerating ROS production and increasing the probability of mitochondrial permeability transition pore (mPTP) opening, whereas low concentrations (1 and 5 M) of C16-carnitine lightly hyperpolarize the m but do not open the mPTP [293]

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Obesity, hypertriglyceridemia, and metabolic syndromeconditions commonly present in patients prescribed GLP-1 agonistsare themselves established risk factors for pancreatic inflammation

M.TargherG.Romero-GomezM.et al (2020)