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Description

Oral administration faces hepatic first-pass metabolism, reducing bioavailability to approximately 4050% of subcutaneous routes, but offers convenience for longer-term studies where daily injections create compliance challenges

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In laboratory adipocyte cultures, the peptide has been observed to stimulate lipolysis the enzymatic breakdown of stored triglycerides into free fatty acids and glycerol while simultaneously inhibiting lipogenesis, the re-esterification of fatty acids back into storage triglyceride

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