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Basically, you're an experienced user who wants max performance and you're okay with the risks

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KRAS: the Achilles heel of pancreas cancer biology

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10.1111/j.1753-4887.2007.tb00311.x 80 KochA.MizrahiV

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Brien, M., Larose, J., Greffard, K., Julien, P., & Bilodeau, J

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Those with moderate to severe non-proliferative diabetic retinopathy or proliferative disease at baseline may experience progression, particularly during the initial months of treatment when glycaemic control improves rapidly

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