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In extreme cases this can be followed by hypotension, a rapid, weak, irregular pulse, breathing difficulty, general weakness, circular, and collapse, finally, convulsions

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Smoking cessation may also increase the concentration of other drugs partially metabolized by the CYP1A2 enzyme, such as imipramine, olanzapine, clomipramine, and fluvoxamine, although data are limited and the possible clinical significance is unknown