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Keywords: Smoking, Inflammation, DAMPs, Endothelial dysfunction, Atherothrombosis 1.Introduction Cardiac and cerebrovascular diseases are the second and fourth leading causes of death in Japan, following malignant neoplasms, and together account for 21.6% (340,000 people a year) of all deaths worldwide 1)

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Smoking Muassel is a traditional social custom in the Middle East