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The transition to the synthetic phenotype contributes to the progression of atherosclerosis, hypertension, and neointima formation [21, 24]

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Of course, in tandem with their efforts to obtain FDA approvals, the manufacturers of these products sought and obtained patent protection, which effectively prohibited other companies from making copycats involving the patented or drug substances (exenatide, semaglutide, and so on)

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This option could be of preference in women with metabolic or cardiovascular conditions that contraindicate the use of estroprogestins [60]