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39 One of the more important aspects of this disease is the chronic inflammatory and oxidative stresses that accompany the infection, which eventually contribute to the loss of CD4 (helper) T-cells, increased opportunistic infections, immuno-deficiency in general, wasting disease, and death

Formed by tightly apposed endothelial cells supported by pericytes and astrocytic end-feet, the BBB restricts the entry of most small molecules, biologics, and nearly all gene-editing constructs [139]

472), glucose is catabolized anaerobically to pyruvate or lactate

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