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Fat sits in storage even when the body needs fuel
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The STEP 1 trial, published in the New England Journal of Medicine, demonstrated 14.9 percent mean body weight reduction with the 2.4mg weekly dose over 68 weeks, compared to just 2.4 percent with placebo
The FDA-approved brand versions have published clinical trial data showing 13.7% average weight loss for semaglutide at maximum dose
Hunger that vanished months ago now appears between meals, subtle but persistent
Extending treatment to one year, the gap widens: about 4% greater weight loss in non-diabetics on semaglutide, and about 5.5% greater on tirzepatide. Some researchers suggest that behavioral differences such as motivation, adherence and engagement in lifestyle changes might help explain this gap
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