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doi: 10.1016/S0140-6736(15)60327-0 Summary Keywords food intake, melanocortin (MC), melanocortin-3 receptor, melanocortin-4 receptor, melanocortin-4 receptor agonist, metabolism, obesity, weight loss Citation Prindle CR, Bennett TL, Rajewski BH, Kelley KJ, Impastato AC, Potterfield R, Marks DL and Delev JY (2026) The melanocortin receptors as targets for general obesity: contextualizing clinical failures and analyzing future perspectives