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A similar observation was made earlier where the alanine substitution of cysteines disrupted the disulfide bond at the proteinprotein interface [45]

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doi:10.1146/annurev-pharmtox-010611-134540, PMID: 23020296 Menzies V, Lyon DE, Archer KJ, Zhou Q, Brumelle J, Jones KH, Gao G, York TP, Jackson-Cook C (2013) Epigenetic alterations and an increased frequency of micronuclei in women with fibromyalgia