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[23] Cardiac-valvular [edit] Cardiac-valvular EDS (cvEDS) is characterized by three major criteria: severe progressive cardiac-valvular problems (affecting aortic and mitral valves), skin problems such as hyperextensibility, atrophic scarring, thin skin, and easy bruising, and joint hypermobility (generalized or restricted to small joints)

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Similarly, Chen et al.30 did a cross-sectional study between the years of 1996 and 1997 assessing 73,364 Canadian individuals

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Matters have perhaps been complicated by the increasing popularity of the e-cigarette