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It further elaborates upon the current status of prophylactic interventions in smokers, thereby leading the discussion to the necessity and scope for therapeutic intervention in smokers including those exposed to SHS

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ROS are potent inducers of cellular apoptosis by promoting the release of cytochrome-C, which may lead to alveolar cell apoptosis, lung tissue damage, inflammation and emphysema [27, 4345]

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But many look like everyday things like pens or USB memory sticks