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None of the other test compounds evoked detectable responses from cells expressing 7 when applied alone at 100 M

Among the studies that do analyze doseresponse relationships, there is large variation in the units and dose categories used in reporting their findings (for example, the use of pack-years or cigarettes per day) 24,25 , which complicates the comparability and consolidation of evidence

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In particular, acute nicotine administration increased responses to conditioned cues and contexts, relative to saline injections 12 and nicotine impaired the inhibition of conditioned threat responses, when situations are safe

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