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Determination of nicotine, nornicotine, nicotine N-oxide, cotinine, trans-3'-hydroxycotinine, and cotinine N-oxide NIC, NOR, NICNO, COT, 3HC, and COTNO in plasma (1 mL) were determined by high-performance liquid chromatography coupled with tandem mass spectrometry using deuterated cotinine as the internal standard, after prior liquidliquid extraction (pH 8, NaOH, dichloromethane-n-propanol in ratio 9:1)

It is a good idea to keep a box of baking soda in the trunk and one open in the center console or near ashtrays every night to help eliminate the smell

Hold the vapour in your mouth for a moment

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