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caution in methylation disorders (use only under supervision) No known drug interactions with oral medications, but B12 may mask B9 (folate) deficiencycombined B-vitamin status should be assessed periodically

NRF2 is a member of the cap n collar (CNC)-bZip transcription factor family that upon recognition of the antioxidant response cis element (ARE) heterodimerizes with small musculoaponeurotic fibrosarcoma (sMAF) proteins to activate transcription (Igarashi et al, 1994

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