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Tobacco consumption patterns vary throughout the Central and South American region, with the highest prevalence rates among adolescents aged 1315 found in the countries of the Southern Cone, such as Chile, with 38.7%, and the lowest rates found in English-speaking Caribbean countries, such as Antigua and Barbuda with 13.5%

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CBD promotes oxaliplatin-mediated autophagy via NOS 3 -mediated mitochondrial dysfunction, implying that NOS 3 is a viable therapeutic target for overcoming oxaliplatin resistance and that CBD could be a novel treatment option for CRC (Jeong et al