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Locally, Republic Act 9711 requires every injectable to carry a Certificate of Product Registration

Unregulated sourcing carries real risks, including contamination and inconsistent dosing, which undermines both safety and results

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In ECs, Ca ++ flux in response to either shear stress or a PIEZO1 agonist, Yoda, leads to cellular ATP release, followed by NO synthesis downstream of the actions of the exported ATP on purinergic receptors and endothelial NO synthase activation secondary to phosphorylation of eNOS by AKT (Wang et al., 2016)

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Sensitivity analysis: Model selection Global sensitivity analysis (GSA) was conducted using the classical Sobol method