Li, C., Vu, K., Hazelgrove, K., & Kuemmerle, J
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The variation between the three tested compounds in absolute AUC raises a concern as it may indicate experimental error in the earlier time points due to rapid degradation or distribution into tissue [47]
Agents that may potentiate acetaminophen intoxication
Given that LCN2 functions as an iron-trafficking protein and that excess iron disrupts mitochondrial integrity, leading to membrane depolarization, dysregulated oxidative phosphorylation (OXPHOS), and ATP depletion, we investigated whether Lcn2 deletion in osteocytes affects mitochondrial function under basal conditions
Comparatively, after co-incubation of M1 macrophages and mBMSCs in the transwell system, a noticeable reduction of the viability of mBMSCs could be detected (Fig