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However, CIs for many sensitivity analyses crossed the null (OR = 1), particularly in MR-Egger, which is known to have lower statistical power due to its reliance on stronger assumptions (e.g., Instrument Strength Independent of Direct Effect)

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Exposure risks to fetal development or infant health remain unstudied

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It works by inhibiting NNMT, the enzyme that methylates nicotinamide and reduces NAD+ availability