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Serum markers of mitochondrial damage and death, including glutamate dehydrogenase (GDH), nuclear DNA (nDNA) and mtDNA have been investigated as clinically useful surrogate markers capable of indicating mitochondrial lysis following hepatocyte necrosis in APAP hepatotoxicity

However, if the provision of precursors for endogenous antioxidants, such as NAC for GSH and/or taurine, enables the body to regulate to optimal levels its own antioxidant defence mechanism, this may be preferable to the use of general exogenous antioxidants such as vitamins C and E

10.1016/j.archoralbio.2017.02.002 Arch

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[13] "These results suggest that we can extend the period of health, termed healthspan , even towards the end of life," said Robbins