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The basic molecular defect results from mutations in the gene encoding the glycoprotein fibrillin-1 ( FBN1 ), which is the main component of microfibrils and helps anchor cells to the extracellular matrix

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In a phase III study published in 2011, the regimen was shown to increase median overall survival by four months compared with Gemzar alone (although the treatment is relatively toxic)

Researchers evaluated aerosol exposures and the potential additive effects of a Western diet on cardiovascular health in multiple cohorts of hyperlipidemic (Apoe-/-) male and female mice