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The World Health Organization reports that tobacco kills more than 8 million people each year, that 80% of the world's tobacco users live in low- and middle-income countries, and that in 2020 22.3% of the world's population used tobacco, including 36.7% of all men and 7.8% of the world's women

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Pulmonary fibrosis was attenuated in P2Y2-deficient mice via a reduction in neutrophil recruitment, migration, and proliferation of fibroblasts and interleukin 6 (IL-6) production (111)