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A large N-terminal extracellular domain (ECD) captures the C-terminal portion of peptide ligands through a "catch and release" mechanism, while the ligand's N-terminal region inserts into the transmembrane domain (TMD) to activate the receptor

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A third ion site (site 3) described for SALSA, SCARA5 and MARCO is not surface-exposed and has been suggested to contribute to structural integrity for those domains 25 (red solid boxes in Fig

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[DOI] [PubMed] [Google Scholar] Meister A, Anderson ME