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While a 2019 study of mice found that those exposed to vaping aerosols experienced fertility problems, with delayed conception (an embryo implanting in the uterus) and smaller offspring, the NHMRC said more research was needed to understand how vaping affects reproductive health in people

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So the nicotine adds up across the refills rather than sitting in the device all at once

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[DOI] [PubMed] [Google Scholar] Durcan MJ, Johnston JA, White J, Gonzales D, Sachs DP, Rigotti N, Niaura R