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The position and local conformation of ECL3 in conformer 2 are more similar to ECL3 in the structures reported for the GLP-1R bound to the small molecules TT-OAD2 70 and CHU-128 12 , which do not contact this loop, than to ECL3 in the structure for the GLP-1R bound to GLP-1 12,40 or conformer 1 bound with Ex4-D-Ala (Fig