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Regulation of -opioid receptors: Desensitization, phosphorylation, internalization, and tolerance

They enhance glucose-dependent insulin secretion, suppress glucagon release, delay gastric emptying, and reduce appetite, thereby contributing to glucose homeostasis and body weight regulation (29, 30)

Write down changes in muscle size, waist circumference, and weight every week

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Any new or worsening symptoms while on therapy, including severe abdominal pain, persistent nausea or vomiting, or signs of gallbladder disease, require prompt medical evaluation