GLP-1 medications like semaglutide follow a standard titration protocol: patients start at a low dose and gradually increase over several months to reach a therapeutic maintenance level
Effective for glycemic control : Helps lower blood glucose and supports weight loss
[DOI] [PMC free article] [PubMed] [Google Scholar] 33.Rakipovski G, et al
In total, 9341 participants (6322 on previously or currently licensed weight management drugs and 3019 on non-drug therapies or placebo) were included
The longer titration is part of why GI side effects, while common, tend to fade
Specifically, effect estimates (MD [95% CI]) for tirzepatide 15 mg vs semaglutide 2.0 mg, tirzepatide 10 mg vs semaglutide 1.0 mg, and tirzepatide 5 mg vs semaglutide 0.5 mg were, respectively, as follows: 3.87 mmol/mol (8.22 to 0.48)