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If the taste of tobacco has become something you want to move away from if you smoke out of habit rather than because you enjoy the flavour then a fruity, approachable TEREA can actually make the transition easier
Real Life Example Imagine Mark smokes 1 pack of cigarettes per day
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Cigarette use varied by grade, with 1.5% of ninth-graders smoking, 3.3% of 10th-graders, 2.5% of 11th-graders, and 4.9% of 12th-graders, according to the 2023 Connecticut School Health Survey
Therefore, in addition to exposure doses that tend to mimic the real-life conditions of e-cigarette use, unrealistically high doses can also be used without being fundamentally objectionable if the ultimate goal is to demonstrate dose-dependent effects that are very helpful in terms of elucidating mechanistic aspects of the toxicological process, even though such doses would neither be applicable nor would make sense in in vivo studies, and thus require special attention when interpreting the results
