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In support of this theory, higher concentration of IL-1a, IL-1, and soluble IL-1RA (sIL-1RA) have been demonstrated in serum of smokers compared to nonsmokers with active autoimmune thyroid disease.[] SMOKING AND THYROID HORMONE LEVELS Due to multiple contrasting pathways in which tobacco smoke can affect the functioning of thyroid gland, individual cross-sectional studies have reported a decrease, an increase, or no effect[] of smoking on the peripheral thyroid hormones [Table 2]

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Functional predictions showed disrupted microbial pathways, including amino acid transport and DNA repair, in smokers

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Environmental tobacco smoke is one of the most widespread and harmful indoor air pollutants to non-smokers both in homes and in workplaces

The prescription medications approved by the FDA include varenicline tartrate and bupropion hydrochloride