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Metformin increased postprandial GLP-1 secretion compared with placebo (P = 0.014), and the postprandial glucose excursions were significantly smaller after metformin + saline compared with metformin + Ex9-39 (P = 0.004)

10.1586/eem.12.3 [DOI] [PubMed] [Google Scholar] 121.Kothbauer-Margreiter I, Sturzenegger M, Komor J, Baumgartner R, Hess CW

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Upon food ingestion and its subsequent entry into the small intestine, intestinal L-cells undergo posttranslational processing of the proglucagon gene, leading to the production of glucagon-like peptide-1 (GLP-1), a potent incretin peptide hormone 9

This is different from standard calorie restriction