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Early detection and prevention may save hundreds of thousands of lives from CVD each year.

Because both mechanisms operate simultaneously and continuously in active smokers, cigarette stains on enamel are considerably more complex and more difficult to treat than the staining caused by dietary sources such as coffee or red wine, which primarily affect only the enamel surface

The nicotine in e-cigarettes can still cause vasoconstriction (narrowing of blood vessels), potentially reducing blood flow to the scalp

doi: 10.1371/journal.ppat.1005591

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