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However, these conditions are rare 9

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doi:10.1111/cen.13120

Activation of FXR stabilizes the nuclear co-repressor (NcoR) at the NF-B response element on the IL-1 promoter, while decreasing the expression of TNF-, IL-1, IL-2, IL-6 and IFN- mRNA, thereby reducing the extent of inflammation (Vavassori et al., 2009)