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GLP-1 receptor activation shifts the balance toward suppression
Obesity is no longer regarded as simply a failure of willpower but now a chronic illness with a biological cause (Couzin-Frankel Dec 2023)
PLoS ONE 8 , e71513 (2013)
This provides a biological basis for considering whether pharmacological GLP-1 therapies, which achieve much higher systemic levels, could also reach the joint and potentially have local effects. Additionally, scientists found that the level of GLP-1 hormone in the synovial fluid is directly tied to the levels in the blood of arthritis patients
A 2025 report found 63% of patients remained on GLP-1s after one year , up from previous years ( [66] ), and easier PA processes may be one factor
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