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A study published in the Journal of Sleep Research found that nicotine consumption before bedtime can cause difficulty falling asleep, frequent awakenings, and overall decreased sleep quality (3)

Dose-response analysis between smoking (pack-years) and ALS We performed a dose-response analysis on five studies (two cohort and three case-control) that provided pack-years information of smoking

Global translational responses to oxidative stress impact upon multiple levels of protein synthesis

Upham, J., Denburg, J

What remains clear is the need for further studies that consider all potential variables