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However, therapeutic strategies targeting this axis continue to face multiple challenges, including limited availability of validated targets, substantial disease heterogeneity, fragmentation of current intervention approaches, and the pressing need to shift from localized symptom control toward comprehensive restoration of systemic immune and neurophysiological homeostasis

I can still be pretty incognito, I should say

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He's been doing some fantastic supporting work in left-field comedic character roles recently, in the HBO series Eastbound & Down (on which he and McKay also serve as co-producers) and Tim & Eric's Billion Dollar Movie (a sketch comedy movie that also, against the odds, works, and was co-produced by Funny or Die)