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But, crucially, aldehydes are also released in tobacco smoke

An American soldier takes a great risk as he strikes a match on one of the trailers, to light his cigarette near Bromskirchen, Germany, on April 7, 1945

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To mitigate the inevitable issue of multicollinearity and potential effect modification among age at initiation, baseline age, and total pack-years, we based our analyses on a large population-wide cohort that allowed stratified analyses according to total pack-years of smoking exposure