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These cells within the premetastatic niche remodel the local microenvironment by secreting inflammatory cytokines, growth factors, and proangiogenic molecules, thus supporting tumor cell colonization, proliferation, and promoting tumor metastasis 83,84,85,86,87,88

This study suggests that larger increases in cigarette prices are necessary to challenge the purchasing decisions of smokers in China, and that environmental smoking restrictions and public education campaigns must be strengthened to increase the impact of price increase as a tobacco control measure.

10.1007/s00535-017-1350-1 J

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10.1016/j.pbb.2008.08.012 54 StilesM