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FIGURE 7 Persistent accumulation of ROS induces lipid peroxidation in keratinocyte membranes and structural proteins, resulting in impaired barrier function and increased TEWL (Yang et al., 2022

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A phase 3 trial of a higher-dose CagriSema formulation at 2.4/7.2 mg is planned for initiation in the second half of 2026, and the REDEFINE 11 trial, exploring CagriSemas full weight-loss potential, is expected to report data in the first half of 2027

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