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How Tirzepatide Works Tirzepatide's dual agonism creates synergistic metabolic effects: GIP receptor activation enhances insulin secretion and may improve fat metabolism GLP-1 receptor activation suppresses glucagon, slows gastric emptying, and reduces appetite Combined pathway stimulation produces greater metabolic benefits than single-pathway agonists Dose-dependent effects allow for personalized titration based on individual response The dual mechanism explains why tirzepatide has demonstrated superior weight loss outcomes compared to single GLP-1 agonists in head-to-head clinical trials

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Supplementary material The Supplementary Material for this article can be found online at: Abbreviations ACTH, Adrenocorticotropic hormone

58 In contrast, the present study highlights the change of an oxidative stress-associated molecule in the chronic stage of SZ and BP