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Medicines and their components cannot be substituted on a one-to-one basis without going through R&D, legal and regulatory approval processes. SEAC questioned the assumption in the dossier that diagnostic laboratory testing including in vitro diagnostic medical devices and calibration of measurement instruments and as analytical reference materials were fully covered under a scientific research & development (SR&D) exemption

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Val 36* is also very central in the hydrophobic Fab-receptor interface and interacts with Ala 101 , Phe 103 and Tyr 108 (CDR3 VH)

Non-cell-autonomous effects of presenilin 1 variants on enrichment-mediated hippocampal progenitor cell proliferation and differentiation