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Relevant literature from clinical trials, mechanistic studies, regulatory reports, and real-world analyses was reviewed to summarize the therapeutic role of semaglutide in obesity

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I dont think it is actually the AI that lowers it directly (I think it is because of lower E2)

By interfering with the interaction between FOXO4 and another protein called p53, the researchers developed a compound called FOXO4-DRI, which specifically targets FOXO4