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The net result was a large decrease in the lactate/pyruvate in all brain regions that occurred after 15 months of age, reflecting an oxidative shift of the brain cytoplasmic [NAD + ]/[NADH] with aging (Ding et al., 2021), opposite to the reductive shift with aging found in C57BL/6J mouse brain

Still, cravings may return during high-stress periods, social events, or times of emotional upheaval

Endocannabinoid receptor pharmacology