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Approximately 0.18% of the starting population survived and settled into a persister state characterized by drug tolerance and negligible growth ( Figures 1C, E )

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Taken together, our data provided evidence that GSH is a critical factor in cystine-regulated cell signaling, but GSH per se is not a direct regulator of the two pathways in HepG2 cells

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Initially developed for type 2 diabetes, these drugs are now widely used for obesity and cardiovascular risk reduction, with emerging applications in neurological disease [2, 3]

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The idea is to help them acclimate before ramping up to higher amounts

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Mecca AP, O'Dell RS, Sharp ES, Banks ER, Bartlett HH, Zhao W, et al

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