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Acetaldehyde induces cytotoxicity by disrupting mitochondrial function to cause oxidative stress in neural cells (Yan et al., 2022), while acrolein causes DNA damage and oxidative stress in non-neural cells (Hikisz and Jacenik, 2023) and is elevated in the brain of patients with neurodegenerative diseases (Liu et al., 2018

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Dr Khaitan also recommended cold turkey as the best way to quit smoking, although she acknowledged the challenge and suggested nicotine patches or professional counselling as alternatives